{"title":"Fypryst","description":"","products":[{"product_id":"fypryst-combo-spot-on-antiparasitic-drops-pipettes-for-dogs-40kg","title":"Fypryst Combo Spot-on for dogs \u003e40 kg 402 mg N1","description":"\u003cp\u003eFypryst Combo Spot-on for dogs \u0026gt;40 kg 402 mg N1\u003c\/p\u003e\n\u003cp\u003eMeans against fleas, ticks for dogs – Fypryst combo dog 402\/361.8 mg (40–60 kg), 1 pip., non-prescription vet. medicine - reg. NO - VA - 089588\/1\u003cbr\u003e\u003cbr\u003eNAME OF THE VETERINARY MEDICINE\u003cbr\u003eFypryst Combo 402 mg\/ 361.8 mg dermal solution for very large dogs\u003cbr\u003e\u003cbr\u003eQUALITATIVE AND QUANTITATIVE COMPOSITION\u003cbr\u003eOne 4.02 ml pipette contains:\u003cbr\u003e\u003cbr\u003eActive substances:\u003cbr\u003eFipronil 402 mg;\u003cbr\u003eS-methoprene 361.8 mg.\u003cbr\u003eExcipients:\u003cbr\u003e\u003cbr\u003eButylhydroxyanisole (E320) 0.80 mg;\u003cbr\u003eButylhydroxytoluene (E321) 0.40 mg;\u003cbr\u003ePovidone (K25);\u003cbr\u003ePolysorbate 80;\u003cbr\u003eEthyl alcohol 96%;\u003cbr\u003eDiethylene glycol monoethyl ether.\u003cbr\u003ePHARMACEUTICAL FORM\u003cbr\u003e\u003cbr\u003eSolution for instillation on the skin.\u003cbr\u003eClear, yellow solution.\u003cbr\u003e\u003cbr\u003eTARGET SPECIES\u003cbr\u003eDogs heavier than 40 kg.\u003c\/p\u003e\n\u003cp\u003eINDICATIONS\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFor the prevention of flea infestations and mixed infestations of fleas and ticks and\/or lice.\u003c\/li\u003e\n\u003cli\u003eFor the treatment of flea (Ctenocephalides spp.) infestation. The effect of the insecticide against the infestation of young adult fleas remains for 8 weeks. For the prevention of flea reproduction by inhibiting the development of eggs (ovicidal action), larvae and pupae (larvicidal action) from eggs laid by adult fleas, 8 weeks after application.\u003c\/li\u003e\n\u003cli\u003eFor the treatment of tick (Ixodes ricinus, Dermacentor variablis, Dermacentor reticulatus, Rhipicephalus sanguineus) infestation. The acaricidal effect of this drug against ticks remains for 4 weeks.\u003c\/li\u003e\n\u003cli\u003eFor the treatment of lice (Trichodectes canis) infestation. This veterinary medicine can be used as part of a treatment strategy for flea allergy dermatitis if it has been previously diagnosed by a veterinarian.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCONTRAINDICATIONS\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDue to a lack of data, this veterinary medicinal product should not be used in puppies under 8 weeks of age and\/or puppies weighing less than 2 kg.\u003c\/li\u003e\n\u003cli\u003eDo not use in sick animals (systemic diseases, fever, etc.) and animals in the recovery period.\u003c\/li\u003e\n\u003cli\u003eDo not use in rabbits, as side effects and even death are possible.\u003c\/li\u003e\n\u003cli\u003eIn the absence of studies, the use of this medicinal product is not recommended in animals other than the target species.\u003c\/li\u003e\n\u003cli\u003eThis medicine is for use in dogs only. Do not use in cats and ferrets, as overdose is possible.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSPECIAL PRECAUTIONS FOR USE\u003cbr\u003eSpecial precautions for use in animals:\u003cbr\u003e\u003cbr\u003eAvoid getting the medicine into the animal's eyes.\u003cbr\u003eIt is important to make sure that the medicine is applied in a place where the animals cannot lick it and to ensure that the animals do not lick each other after treatment.\u003c\/p\u003e\n\u003cp\u003eSpecial precautions to be taken by a person using veterinary medicinal products for the treatment of animals:\u003cbr\u003e\u003cbr\u003eThis medicine can cause irritation of the mucous membrane, skin and eyes, so avoid contact of the medicine with the mucous membrane of the mouth, skin and eyes.\u003cbr\u003ePersons with known hypersensitivity to insecticides or alcohol should avoid contact with this veterinary medicinal product. Be careful not to let the medicine come into contact with the skin. If this has happened, wash your hands with soap and water.\u003cbr\u003eIf the medicine accidentally gets into the eyes, rinse the eyes thoroughly with clean water.\u003cbr\u003eWash hands after use.\u003cbr\u003eDo not smoke, drink or eat during treatment.\u003cbr\u003eTreated animals should not be petted until the application site is dry, and children should not be allowed to play with freshly treated animals. For this reason, it is recommended to treat animals not during the day, but early in the evening, and not to allow recently treated animals to sleep with their owners, especially children.\u003cbr\u003eOther Precautions:\u003cbr\u003e\u003cbr\u003eFipronil and S-methoprene may be hazardous to aquatic organisms. Dogs should not be allowed to swim in water for two days after taking the medicine\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003ePOSSIBLE SIDE EFFECTS\u003cbr\u003eAmong the very rare (less than 1 animal in 10,000 animals treated, including individual reports) possible side effects after the use of the drug, transient skin reactions at the application site (skin discoloration, local alopecia, pruritus, erythema) and generalized itching or hair loss have been reported. Increased salivation, depression, reversible neurological symptoms (increased sensitivity, depression, nervous symptoms), vomiting or respiratory symptoms have also been observed after taking the drug.\u003cbr\u003eIn case of licking the application site, temporary increased salivation may be observed mainly due to the properties of the carrier.\u003c\/p\u003e\n\u003cp\u003eUSE DURING PREGNANCY, LACTATION OR LAYING\u003cbr\u003eMay be used during pregnancy and lactation.\u003cbr\u003e\u003cbr\u003eINTERACTIONS WITH OTHER DRUGS AND OTHER TYPES OF INTERACTIONS\u003cbr\u003eNot known.\u003c\/p\u003e\n\u003cp\u003eDOSAGE AND METHOD OF ADMINISTRATION\u003cbr\u003e\u003cbr\u003eDosage:\u003cbr\u003eFor external use only (instillation).\u003cbr\u003eUse by applying to the skin; one 4.02 ml pipette (402 mg fipronil + 361.8 mg (S)-methoprene) for dogs weighing more than 40 kg.\u003cbr\u003eThis corresponds to the minimum recommended dose of 6.7 mg\/kg fipronil and 6 mg\/kg (S)-methoprene for dermal application.\u003cbr\u003eDue to the lack of drug safety studies, the minimum interval between applications is 4 weeks.\u003cbr\u003eMethod of use:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRemove the pipette from the package. Hold the pipette vertically with the cap upwards, unscrew and remove the cap.\u003c\/li\u003e\n\u003cli\u003eTurn the cap upside down and put the other end back on the pipette. Press and twist the cap to break the seal and then remove the cap from the pipette.\u003c\/li\u003e\n\u003cli\u003eApply to the skin at the base of the neck in front of the shoulder blades.\u003c\/li\u003e\n\u003cli\u003ePart the hair so that the skin is visible. Place the tip of the pipette on the skin and squeeze the single-dose pipette several times to empty the contents directly onto the skin at one point.\u003c\/li\u003e\n\u003cli\u003eTransient changes in the coat (sticky\/greasy coat) may appear at the site of application.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eOVERDOSE\u003cbr\u003eIn laboratory studies on the safety of the drug, no side effects were observed in 8-month-old puppies, growing dogs, and dogs weighing around 2 kg, at a single dose of five times the recommended dose.\u003cbr\u003eThe risk of side effects can increase with an overdose of the drug, so choose the most suitable pipette size for animals, taking into account the animal's body weight.\u003cbr\u003ePHARMACOLOGICAL PROPERTIES\u003cbr\u003e\u003cbr\u003ePharmacotherapeutic group: means against ectoparasites for external use, including insecticides.\u003c\/p\u003e\n\u003cp\u003ePharmacodynamic properties:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFipronil is an insecticide and acaricide belonging to the phenylpyrazole group. It interacts with ligand-gated chloride channels, especially those regulated by the neurotransmitter gamma-aminobutyric acid (GASS), thereby blocking the pre- and postsynaptic transfer of chloride ions across cell membranes. It causes uncontrolled central nervous system activity and death in insects and mites. Fipronil kills fleas within 24 hours, ticks (Dermacentor variablis, Dermacentor reticulatus, Rhipicephalus sanguineus, Ixodes ricinus) and lice 48 hours after application.\u003c\/li\u003e\n\u003cli\u003e(S)-Methoprene is an insect growth regulator (IAR), from a class of compounds known as juvenile hormone analogues, which arrest the development of insects at one stage of development. This substance acts similar to juvenile hormones and causes impaired development and death of fleas at all stages of their development. The ovicidal effect of (S)-methoprene on the animal occurs either by direct penetration into newly laid eggs or by penetration through the cuticle into the body of an adult flea. (S)-methoprene effectively stops the further development of flea eggs and larvae, which protects against contamination of the immediate surroundings of animals with fleas in various stages of their development.\u003c\/li\u003e\n\u003cli\u003e \u003c\/li\u003e\n\u003cli\u003eFypryst Combo Spot-on for dogs \u0026gt;40 kg 402 mg N1\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Fypryst","offers":[{"title":"Default Title","offer_id":46902985752901,"sku":"4017-1","price":5.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0552\/4327\/6372\/files\/sredstvo-ot-blokh-kleshhejj-dlja-sobak-fypryst-combo-dog-402-361-8-mg-40-60-kg-1-pipetka-bezrecepturnyjj-preparat-reg-nr-va-072463-3-original_d9baf2b5-4fde-4a63-bc8f-4935ed9c6ff2.jpg?v=1695299105"},{"product_id":"fypryst-combo-spot-on-antiparasitic-drops-pipettes-for-dogs-20-40kg","title":"Fypryst Combo Spot-on for dogs 20-40 kg 268 mg N1","description":"\u003cp\u003eFypryst Combo Spot-on for dogs 20-40 kg 268 mg N1\u003c\/p\u003e\n\u003cp\u003eMeans against fleas, ticks for dogs - Fypryst combo dog 268\/241.2 mg (20-40 kg), 1 pip., non-prescription vet. medicine - reg. NO - VA - 089588\/1\u003cbr\u003e\u003cbr\u003eNAME OF THE VETERINARY MEDICINE\u003cbr\u003eFypryst Combo 268 mg\/241.2 mg topical solution for large dogs.\u003cbr\u003e\u003cbr\u003eQUALITATIVE AND QUANTITATIVE COMPOSITION\u003cbr\u003eOne 2.68 ml pipette contains:\u003cbr\u003e\u003cbr\u003eActive substances:\u003cbr\u003eFipronil 268 mg;\u003cbr\u003eS-methoprene 241.2 mg.\u003cbr\u003eExcipients:\u003cbr\u003e\u003cbr\u003eButylhydroxyanisole (E320) 0.54 mg;\u003cbr\u003eButylhydroxytoluene (E321) 0.27 mg;\u003cbr\u003ePovidone (K25);\u003cbr\u003ePolysorbate 80;\u003cbr\u003eEthyl alcohol 96%;\u003cbr\u003eDiethylene glycol monoethyl ether.\u003c\/p\u003e\n\u003cp\u003ePHARMACEUTICAL FORM\u003cbr\u003eSolution for instillation on the skin.\u003cbr\u003eClear, yellow solution.\u003cbr\u003e\u003cbr\u003eTARGET SPECIES\u003cbr\u003eDogs 20-40 kg.\u003cbr\u003e\u003cbr\u003eINDICATIONS\u003cbr\u003eFor the prevention of flea infestations and mixed infestations of fleas and ticks and\/or lice.\u003cbr\u003eFor the treatment of flea (Ctenocephalides spp.) infestation. The effect of the insecticide against the infestation of young adult fleas remains for 8 weeks. For the prevention of flea reproduction by inhibiting the development of eggs (ovicidal action), larvae and pupae (larvicidal action) from eggs laid by adult fleas, 8 weeks after application.\u003cbr\u003eFor the treatment of tick (Ixodes ricinus, Dermacentor variablis, Dermacentor reticulatus, Rhipicephalus sanguineus) infestation. The acaricidal effect of this drug against ticks remains for 4 weeks.\u003cbr\u003eFor the treatment of lice (Trichodectes canis) infestation. This veterinary medicine can be used as part of a treatment strategy for flea allergy dermatitis if it has been previously diagnosed by a veterinarian.\u003c\/p\u003e\n\u003cp\u003eCONTRAINDICATIONS\u003cbr\u003eDue to a lack of data, this veterinary medicinal product should not be used in puppies under 8 weeks of age and\/or puppies weighing less than 2 kg.\u003cbr\u003eDo not use in sick animals (systemic diseases, fever, etc.) and animals in the recovery period.\u003cbr\u003eDo not use in rabbits, as side effects and even death are possible.\u003cbr\u003eIn the absence of studies, the use of this medicinal product is not recommended in animals other than the target species.\u003cbr\u003eThis medicine is for use in dogs only. Do not use in cats and ferrets, as overdose is possible.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003eSPECIAL PRECAUTIONS FOR USE\u003cbr\u003eSpecial precautions for use in animals:\u003cbr\u003e\u003cbr\u003eAvoid getting the medicine into the animal's eyes.\u003cbr\u003eIt is important to make sure that the medicine is applied in a place where the animals cannot lick it and to ensure that the animals do not lick each other after treatment.\u003cbr\u003eSpecial precautions to be taken by a person using veterinary medicinal products for the treatment of animals:\u003cbr\u003e\u003cbr\u003eThis medicine can cause irritation of the mucous membrane, skin and eyes, so avoid contact of the medicine with the mucous membrane of the mouth, skin and eyes.\u003cbr\u003ePersons with known hypersensitivity to insecticides or alcohol should avoid contact with this veterinary medicinal product. Be careful not to let the medicine come into contact with the skin. If this has happened, wash your hands with soap and water.\u003cbr\u003eIf the medicine accidentally gets into the eyes, rinse the eyes thoroughly with clean water.\u003cbr\u003eWash hands after use.\u003cbr\u003eDo not smoke, drink or eat during treatment.\u003cbr\u003eTreated animals should not be petted until the application site is dry, and children should not be allowed to play with freshly treated animals. For this reason, it is recommended to treat animals not during the day, but early in the evening, and not to allow recently treated animals to sleep with their owners, especially children.\u003c\/p\u003e\n\u003cp\u003eOther Precautions:\u003cbr\u003eFipronil and S-methoprene may be hazardous to aquatic organisms. Dogs should not be allowed to swim in water for two days after taking the medicine.\u003cbr\u003ePOSSIBLE SIDE EFFECTS\u003cbr\u003e\u003cbr\u003eAmong the very rare (less than 1 animal in 10,000 animals treated, including individual reports) possible side effects after the use of the drug, transient skin reactions at the application site (skin discoloration, local alopecia, pruritus, erythema) and generalized itching or hair loss have been reported. Increased salivation, depression, reversible neurological symptoms (increased sensitivity, depression, nervous symptoms), vomiting or respiratory symptoms have also been observed after taking the drug.\u003cbr\u003eIn case of licking the application site, temporary increased salivation may be observed mainly due to the properties of the carrier.\u003c\/p\u003e\n\u003cp\u003eUSE DURING PREGNANCY, LACTATION OR LAYING\u003cbr\u003eMay be used during pregnancy and lactation.\u003cbr\u003e\u003cbr\u003eINTERACTIONS WITH OTHER DRUGS AND OTHER TYPES OF INTERACTIONS\u003cbr\u003eNot known.\u003cbr\u003e\u003cbr\u003eDOSAGE AND METHOD OF ADMINISTRATION\u003cbr\u003eDosage:\u003cbr\u003eFor external use only (instillation).\u003cbr\u003eUse by applying to the skin; one 2.68 ml pipette (268 mg fipronil + 241.2 mg (S)-methoprene) for a dog with a body weight above 20 kg and up to 40 kg.\u003cbr\u003eThis corresponds to the minimum recommended dose of 6.7 mg\/kg fipronil and 6 mg\/kg (S)-methoprene for dermal application.\u003cbr\u003eDue to the lack of drug safety studies, the minimum interval between applications is 4 weeks.\u003c\/p\u003e\n\u003cp\u003eMethod of use:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRemove the pipette from the package. Hold the pipette vertically with the cap upwards, unscrew and remove the cap.\u003c\/li\u003e\n\u003cli\u003eTurn the cap upside down and put the other end back on the pipette. Press and twist the cap to break the seal and then remove the cap from the pipette.\u003c\/li\u003e\n\u003cli\u003eApply to the skin at the base of the neck in front of the shoulder blades.\u003c\/li\u003e\n\u003cli\u003ePart the hair so that the skin is visible. Place the tip of the pipette on the skin and squeeze the single-dose pipette several times to empty the contents directly onto the skin at one point.\u003c\/li\u003e\n\u003cli\u003eTransient changes in the coat (sticky\/greasy coat) may appear at the site of application.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eOVERDOSE\u003cbr\u003eIn laboratory studies on the safety of the drug, no side effects were observed in 8-month-old puppies, growing dogs, and dogs weighing around 2 kg, at a single dose of five times the recommended dose.\u003cbr\u003eThe risk of side effects can increase with an overdose of the drug, so choose the most suitable pipette size for animals, taking into account the animal's body weight.\u003cbr\u003ePHARMACOLOGICAL PROPERTIES\u003cbr\u003e\u003cbr\u003ePharmacotherapeutic group: means against ectoparasites for external use, including insecticides.\u003c\/p\u003e\n\u003cp\u003ePharmacodynamic properties:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFipronil is an insecticide and acaricide belonging to the phenylpyrazole group. It interacts with ligand-gated chloride channels, especially those regulated by the neurotransmitter gamma-aminobutyric acid (GASS), thereby blocking the pre- and postsynaptic transfer of chloride ions across cell membranes. It causes uncontrolled central nervous system activity and death in insects and mites. Fipronil kills fleas within 24 hours, ticks (Dermacentor variablis, Dermacentor reticulatus, Rhipicephalus sanguineus, Ixodes ricinus) and lice 48 hours after application.\u003c\/li\u003e\n\u003cli\u003e(S)-Methoprene is an insect growth regulator (IAR), from a class of compounds known as juvenile hormone analogues, which arrest the development of insects at one stage of development. This substance acts similar to juvenile hormones and causes impaired development and death of fleas at all stages of their development. The ovicidal effect of (S)-methoprene on the animal occurs either by direct penetration into newly laid eggs or by penetration through the cuticle into the body of an adult flea. (S)-methoprene effectively stops the further development of flea eggs and larvae, which protects against contamination of the immediate surroundings of animals with fleas in various stages of their development.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFypryst Combo Spot-on for dogs 20-40 kg 268 mg N1\u003c\/p\u003e","brand":"Fypryst","offers":[{"title":"Default Title","offer_id":46902985818437,"sku":"4016-1","price":5.19,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0552\/4327\/6372\/files\/lidzeklis-pret-blusam-ercem-suniem-fypryst-combo-dog-268-241-2-mg-20-40-kg-1-pip-bezrecepsu-vet-zales-reg-nr-va-072463-3-original_1cbf4a97-8787-444f-9a7c-c6101df9c165.jpg?v=1695300073"},{"product_id":"fypryst-combo-spot-on-antiparasitic-drops-pipettes-for-dogs-10-20kg","title":"Fypryst Combo Spot-on for Medium Dogs 10-20 kg, 1 pipette","description":"\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003eFypryst Combo Spot-on for Medium Dogs 10-20 kg, 1 pipette\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003eFypryst Combo Spot-on Antiparasitic Drops for Medium Dogs 10-20 kg, 1 Pipette 134 mg\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\/120.6 mg,\u003c\/span\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e non-prescription vet. medicine - reg. NO - VA - 089588\/1.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003eEffective Parasite Protection:\u003c\/strong\u003e Safeguard your medium-sized dogs (10-20 kg) from parasites with Fypryst Combo Spot-on. This 134 mg single pipette treatment is formulated to combat fleas, ticks, and biting lice effectively.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003eBroad Spectrum Control:\u003c\/strong\u003e Fypryst Combo not only kills adult fleas but also interrupts their life cycle by inhibiting the development of flea eggs and larvae, ensuring comprehensive protection against future infestations.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003eEasy to Apply:\u003c\/strong\u003e The spot-on application allows for a straightforward and mess-free treatment. Apply the solution directly to your dog's skin, typically at the back of the neck, for fast-acting and lasting relief.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003eSafety and Comfort:\u003c\/strong\u003e Designed to be safe for dogs weighing between 10 and 20 kg. It minimizes the discomfort and health risks associated with parasites, keeping your dog happy and healthy.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003eRecommended Use:\u003c\/strong\u003e Ideal for regular use in ongoing parasite control programs. Check with your vet for detailed usage instructions and optimal treatment schedules.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003eQUALITATIVE AND QUANTITATIVE COMPOSITION\u003c\/span\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003cbr style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eOne 1.34 ml pipette contains:\u003c\/span\u003e\u003cbr style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003eActive substances:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003cbr style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eFipronil 134 mg;\u003c\/span\u003e\u003cbr style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eS-methoprene 120.6 mg.\u003c\/span\u003e\u003cbr style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eExcipients:\u003c\/span\u003e\u003cbr style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eButylhydroxyanisole (E320) 0.27 mg;\u003c\/span\u003e\u003cbr style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eButylhydroxytoluene (E321) 0.13 mg;\u003c\/span\u003e\u003cbr style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003ePovidone (K25);\u003c\/span\u003e\u003cbr style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003ePolysorbate 80;\u003c\/span\u003e\u003cbr style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eEthyl alcohol 96%;\u003c\/span\u003e\u003cbr style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eDiethylene glycol monoethyl ether.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003e\u003cstrong\u003ePHARMACOLOGICAL PROPERTIES\u003c\/strong\u003e\u003cbr\u003ePharmacotherapeutic group: means against ectoparasites for external use, including insecticides.\u003cbr\u003ePharmacodynamic properties:\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eFipronil is an insecticide and acaricide belonging to the phenylpyrazole group. It interacts with ligand-gated chloride channels, especially those regulated by the neurotransmitter gamma-aminobutyric acid (GASS), thereby blocking the pre- and postsynaptic transfer of chloride ions across cell membranes. It causes uncontrolled central nervous system activity and death in insects and mites. Fipronil kills fleas within 24 hours, ticks (Dermacentor variablis, Dermacentor reticulatus, Rhipicephalus sanguineus, Ixodes ricinus) and lice 48 hours after application.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003e(S)-Methoprene is an insect growth regulator (IAR), from a class of compounds known as juvenile hormone analogues, which arrest the development of insects at one stage of development. This substance acts similar to juvenile hormones and causes impaired development and death of fleas at all stages of their development. The ovicidal effect of (S)-methoprene on the animal occurs either by direct penetration into newly laid eggs or by penetration through the cuticle into the body of an adult flea. (S)-methoprene effectively stops the further development of flea eggs and larvae, which protects against contamination of the immediate surroundings of animals with fleas in various stages of their development.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003eTARGET SPECIES: \u003c\/span\u003e\u003c\/strong\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003eDogs 10-20 kg.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif;\"\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003eINDICATIONS\u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eFor the prevention of flea infestations and mixed infestations of fleas and ticks and\/or lice.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eFor the treatment of flea (Ctenocephalides spp.) infestation. The effect of the insecticide against the infestation of young adult fleas remains for 8 weeks. For the prevention of flea reproduction by inhibiting the development of eggs (ovicidal action), larvae and pupae (larvicidal action) from eggs laid by adult fleas, 8 weeks after application.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eFor the treatment of tick (Ixodes ricinus, Dermacentor variablis, Dermacentor reticulatus, Rhipicephalus sanguineus) infestation. The acaricidal effect of this drug against ticks remains for 4 weeks.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eFor the treatment of lice (Trichodectes canis) infestation. This veterinary medicine can be used as part of a treatment strategy for flea allergy dermatitis if it has been previously diagnosed by a veterinarian.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif;\"\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003eCONTRAINDICATIONS\u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eDue to a lack of data, this veterinary medicinal product should not be used in puppies under 8 weeks of age and\/or puppies weighing less than 2 kg.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eDo not use in sick animals (systemic diseases, fever, etc.) and animals in the recovery period.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eDo not use in rabbits, as side effects and even death are possible.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eIn the absence of studies, the use of this medicinal product is not recommended in animals other than the target species.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eThis medicine is for use in dogs only. Do not use in cats and ferrets, as overdose is possible.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003e\u003cstrong\u003eSpecial precautions for use in animals:\u003c\/strong\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eAvoid getting the medicine into the animal's eyes.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eIt is important to make sure that the medicine is applied in a place where the animals cannot lick it and to ensure that the animals do not lick each other after treatment.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eSpecial precautions to be taken by a person using veterinary medicinal products for the treatment of animals\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eThis medicine can cause irritation of the mucous membrane, skin and eyes, so avoid contact of the medicine with the mucous membrane of the mouth, skin and eyes.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003ePersons with known hypersensitivity to insecticides or alcohol should avoid contact with this veterinary medicinal product. Be careful not to let the medicine come into contact with the skin. If this has happened, wash your hands with soap and water.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eIf the medicine accidentally gets into the eyes, rinse the eyes thoroughly with clean water.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eWash hands after use.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eDo not smoke, drink or eat during treatment.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eTreated animals should not be petted until the application site is dry, and children should not be allowed to play with freshly treated animals. For this reason, it is recommended to treat animals not during the day, but early in the evening, and not to allow recently treated animals to sleep with their owners, especially children.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003e\u003cstrong\u003eOther Precautions:\u003c\/strong\u003e\u003cbr\u003eFipronil and S-methoprene may be hazardous to aquatic organisms. Dogs should not be allowed to swim in water for two days after taking the medicine.\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003e\u003cstrong\u003ePOSSIBLE SIDE EFFECTS\u003c\/strong\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eAmong the very rare (less than 1 animal in 10,000 animals treated, including individual reports) possible side effects after the use of the drug, transient skin reactions at the application site (skin discoloration, local alopecia, pruritus, erythema) and generalized itching or hair loss have been reported. Increased salivation, depression, reversible neurological symptoms (increased sensitivity, depression, nervous symptoms), vomiting or respiratory symptoms have also been observed after taking the drug.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eIn case of licking the application site, temporary increased salivation may be observed mainly due to the properties of the carrier.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003e\u003cstrong\u003eUSE DURING PREGNANCY, LACTATION OR LAYING\u003c\/strong\u003e\u003cbr\u003eMay be used during pregnancy and lactation.\u003cbr\u003e\u003cbr\u003eINTERACTIONS WITH OTHER DRUGS AND OTHER TYPES OF INTERACTIONS\u003cbr\u003eNot known.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003eWay To Use:\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #000000; font-size: 0.875rem;\"\u003eFor external use only (instillation).\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"color: #000000; font-size: 0.875rem;\"\u003eUse by applying to the skin; one 1.34 ml pipette (134 mg fipronil + 120.6 mg (S)-methoprene) for a dog with a body weight over 10 and up to 20 kg.\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"color: #000000; font-size: 0.875rem;\"\u003eThis corresponds to the minimum recommended dose of 6.7 mg\/kg fipronil and 6 mg\/kg (S)-methoprene for dermal application.\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"color: #000000; font-size: 0.875rem;\"\u003eDue to the lack of drug safety studies, the minimum interval between applications is 4 weeks.\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"color: #000000; font-size: 0.875rem;\"\u003eRemove the pipette from the package. Hold the pipette vertically with the cap upwards, unscrew and remove the cap.\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 0.875rem; color: #000000;\"\u003eTurn the cap upside down and put the other end back on the pipette. Press and twist the cap to break the seal and then remove the cap from the pipette.\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 0.875rem; color: #000000;\"\u003eApply to the skin at the base of the neck in front of the shoulder blades.\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 0.875rem; color: #000000;\"\u003ePart the hair so that the skin is visible. Place the tip of the pipette on the skin and squeeze the single-dose pipette several times to empty the contents directly onto the skin at one point.\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 0.875rem; color: #000000;\"\u003eTransient changes in the coat (sticky\/greasy coat) may appear at the site of application.\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"color: #000000;\"\u003e \u003cstrong style=\"font-size: 0.875rem;\"\u003eOVERDOSE\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem; color: #000000;\"\u003eIn laboratory studies on the safety of the medicine, no side effects were observed in 8-month-old puppies, growing dogs, and dogs weighing around 2 kg, at a single dose of five times the recommended dose.\u003cbr\u003eThe risk of side effects can increase with an overdose of the drug, so choose the most suitable pipette size for animals, taking into account the animal's body weight.\u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv\u003eFypryst Combo Spot-on for Medium Dogs 10-20 kg, 1 pipette\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003eStill have any questions?\u003c\/strong\u003e\u003cspan class=\"apple-converted-space\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003e\u003ca style=\"color: #2b00ff;\" href=\"https:\/\/zuzu.land\/pages\/services\" target=\"_blank\" rel=\"noopener\"\u003eSign up\u003c\/a\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003cspan class=\"apple-converted-space\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/span\u003e\u003cstrong\u003efor an online consultation with our licensed veterinary specialists. Online consults are a supplement to clinic visits - we don’t prescribe or diagnose.\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003e\u003ca style=\"color: #2b00ff;\" title=\"Online veterinary services\" href=\"https:\/\/zuzu.land\/pages\/services\" target=\"_blank\" rel=\"noopener\"\u003eOnline Vet Help Is Just a Click Away!\u003c\/a\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Fypryst","offers":[{"title":"Default Title","offer_id":46902985883973,"sku":"4015-1","price":5.5,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0552\/4327\/6372\/files\/fypryst-combo-kozni-nanos-za-srednje-velike-pse-10-do-20kg-1-pipeta_a89dbbbd-1d9e-49fa-9548-3bcc82a0a995.jpg?v=1695212503"},{"product_id":"fypryst-combo-spot-on-antiparasitic-drops-pipettes-for-dogs-2-10kg","title":"Fypryst Combo Spot-on for dogs 2-10 kg 67mg N1","description":"\u003cp\u003eFypryst Combo Spot-on for dogs 2-10 kg 67mg N1\u003c\/p\u003e\n\u003cp\u003eMeans against fleas, ticks for dogs - Fypryst combo dog 67\/60.3 mg (2-10 kg), 1 pip., non-prescription vet. medicine - reg. NO - VA -089588\/1\u003cbr\u003e\u003cbr\u003eNAME OF THE VETERINARY MEDICINE\u003cbr\u003eFypryst Combo 67 mg\/ 63 mg solution for instillation on the skin of small dogs.\u003cbr\u003e\u003cbr\u003eQUALITATIVE AND QUANTITATIVE COMPOSITION\u003cbr\u003eOne 1.34 ml pipette contains:\u003cbr\u003e\u003cbr\u003eActive substances:\u003cbr\u003eFipronil 67 mg;\u003cbr\u003e\u003cbr\u003eExcipients:\u003cbr\u003eButylhydroxyanisole (E320) 0.134 mg;\u003cbr\u003eButylhydroxytoluene (E321) 0.067 mg;\u003cbr\u003eEthanol (96%)\u003cbr\u003ePolysorbate 80\u003cbr\u003ePovidone K25\u003cbr\u003eDiethylene glycol monoethyl ether.\u003cbr\u003e\u003cbr\u003ePHARMACEUTICAL FORM:\u003cbr\u003eSolution for instillation on the skin.\u003cbr\u003eClear, yellow solution.\u003c\/p\u003e\n\u003cp\u003eTARGET SPECIES:\u003cbr\u003e\u003cbr\u003eDogs 2-10 kg.\u003cbr\u003e\u003cbr\u003eINDICATIONS:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFleas (Ctenocephalides felis) and ticks (Rhipicephalus species, Dermacentor species, Ixodes species)\u003c\/li\u003e\n\u003cli\u003etreatment and prevention of infestation in dogs.\u003c\/li\u003e\n\u003cli\u003eTreatment and control of allergy to flea bites in dogs (flea bite allergies).\u003c\/li\u003e\n\u003cli\u003ePrevention and treatment of lice (Trichodectes canis) infestation in dogs\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003eCONTRAINDICATIONS:\u003cbr\u003eAs safety studies of this veterinary medicinal product have not been carried out, do not use in puppies under 8 weeks of age and\/or\u003cbr\u003efor puppies with a body weight of up to 2 kg.\u003cbr\u003eDo not use in sick animals (systemic diseases, fever) or animals recovering\u003cbr\u003eperiod.\u003cbr\u003eDo not use in rabbits, as side effects and even death may occur.\u003cbr\u003eThis medicine is intended for dogs. Do not use in cats, as overdose is possible.\u003cbr\u003e\u003cbr\u003eSPECIAL PRECAUTIONS FOR USE:\u003cbr\u003e\u003cbr\u003eSpecial precautions for use in animals:\u003cbr\u003eAvoid getting the medicine into the animal's eyes.\u003cbr\u003eIt is important to make sure that the medicine is applied in a place where the animals cannot lick it and to ensure that the animals do not lick each other after treatment.\u003cbr\u003e\u003cbr\u003eSpecial precautions to be taken by a person using veterinary medicinal products for the treatment of animals:\u003cbr\u003e\u003cbr\u003eThis medicine can cause irritation of the mucous membrane, skin and eyes, so avoid contact of the medicine with the mucous membrane of the mouth, skin and eyes.\u003cbr\u003ePersons with known hypersensitivity to insecticides or alcohol should avoid contact with this veterinary medicinal product. Be careful not to let the medicine come into contact with the skin. If this has happened, wash your hands with soap and water.\u003cbr\u003eIf the medicine accidentally gets into the eyes, rinse the eyes thoroughly with clean water.\u003cbr\u003eWash hands after use.\u003cbr\u003eDo not smoke, drink or eat during treatment.\u003cbr\u003eTreated animals should not be petted until the application site is dry, and children should not be allowed to play with freshly treated animals. For this reason, it is recommended to treat animals not during the day, but early in the evening, and not to allow recently treated animals to sleep with their owners, especially children.\u003c\/p\u003e\n\u003cp\u003ePOSSIBLE SIDE EFFECTS:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIn the case of licking, temporary hypersalivation (excessive salivation) can be observed mainly\u003c\/li\u003e\n\u003cli\u003edue to the properties of the ingredients.\u003c\/li\u003e\n\u003cli\u003eAmong the very rare side effects reported after use are transient skin reactions\u003c\/li\u003e\n\u003cli\u003eapplication site (scaling, local alopecia, pruritus, erythema) and generalized pruritus or alopecia.\u003c\/li\u003e\n\u003cli\u003eIn some cases, increased hypersalivation was observed after use, reversible neurologically\u003c\/li\u003e\n\u003cli\u003esymptoms (hypersensitivity, depression, nervous symptoms) or vomiting.\u003c\/li\u003e\n\u003cli\u003eDo not overdose!\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003eUSE DURING PREGNANCY, LACTATION OR LAYING:\u003cbr\u003eMay be used during pregnancy and lactation.\u003cbr\u003e\u003cbr\u003eINTERACTIONS WITH OTHER DRUGS AND OTHER TYPES OF INTERACTIONS:\u003cbr\u003eNot known.\u003cbr\u003e\u003cbr\u003eDOSAGE AND METHOD OF USE:\u003cbr\u003eDosage:\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eOne single-dose pipette with 0.67 ml of solution for instillation on the skin of dogs with a body weight of 2 to 10 kg.\u003c\/li\u003e\n\u003cli\u003eThis will give you the minimum recommended fipronil dose of 6.7 mg\/kg.\u003c\/li\u003e\n\u003cli\u003eSince there have been no studies on the safety of the drug, the minimum interval between applications is 4 weeks.\u003c\/li\u003e\n\u003cli\u003eIf there is a high risk of repeated flea infestation, if the dog is allergic to flea bites, if necessary\u003c\/li\u003e\n\u003cli\u003etick infestation control or if the dog is washed frequently using hypoallergenic or emollients\u003c\/li\u003e\n\u003cli\u003eshampoos, recommended treatment once a month. In areas where there is no serious risk of flea and tick infestation,\u003c\/li\u003e\n\u003cli\u003eFypryst solution for drops on the skin can be used once every two or three months.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMethod of use:\u003cbr\u003e\u003cbr\u003eRemove the pipette from the package. Hold the pipette vertically with the cap upwards, unscrew and remove the cap.\u003cbr\u003eTurn the cap upside down and put the other end back on the pipette. Press and twist the cap to break the seal and then remove the cap from the pipette.\u003cbr\u003eApply to the skin at the base of the neck in front of the shoulder blades.\u003cbr\u003ePart the hair so that the skin is visible. Place the tip of the pipette on the skin and squeeze the single-dose pipette several times to empty the contents directly onto the skin at one point.\u003cbr\u003eTransient changes in the coat (sticky\/greasy coat) may appear at the site of application.\u003cbr\u003e\u003cbr\u003eOVERDOSE:\u003cbr\u003eIn laboratory studies on the safety of the drug, no side effects were observed in 8-month-old puppies, growing dogs, and dogs weighing around 2 kg, at a single dose of five times the recommended dose.\u003cbr\u003eThe risk of side effects can increase with an overdose of the drug, so choose the most suitable pipette size for animals, taking into account the animal's body weight.\u003cbr\u003e\u003cbr\u003ePHARMACOLOGICAL PROPERTIES:\u003cbr\u003ePharmacotherapeutic group: means against ectoparasites for external use, including insecticides.\u003cbr\u003e\u003cbr\u003ePharmacodynamic properties:\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAfter topical application of Fypryst solution to the skin in dogs, fipronil moderate (15% by volume)\u003c\/li\u003e\n\u003cli\u003eabsorbed. Different concentrations of fipronil have been observed in the blood plasma of dogs.\u003c\/li\u003e\n\u003cli\u003eAfter application of Fypryst solution to the skin, fipronil by concentration gradient mechanism\u003c\/li\u003e\n\u003cli\u003eon animal skin and hair spreads from the application area to the peripheral areas (hip area,\u003c\/li\u003e\n\u003cli\u003egroins, etc.).\u003c\/li\u003e\n\u003cli\u003eIn dogs, fipronil is primarily metabolized to its sulfone (RM 1602), which also has\u003c\/li\u003e\n\u003cli\u003einsecticide and acaricidal effect.\u003c\/li\u003e\n\u003cli\u003e56 days after application, the concentration of fipronil in the hair of dogs decreases to approximately 3-4 μg\/g.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFypryst Combo Spot-on for dogs 2-10 kg 67mg N1\u003c\/p\u003e","brand":"Fypryst","offers":[{"title":"Default Title","offer_id":46902985916741,"sku":"4014-1","price":4.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0552\/4327\/6372\/files\/lidzeklis-pret-blusam-ercem-suniem-fypryst-combo-dog-67-60-3-mg-2-10-kg-1-pip-bezrecepsu-vet-zales-reg-nr-va-072463-3-default_1204b906-950c-48f4-8d9f-28a42d73a9bb.png?v=1695368241"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0552\/4327\/6372\/collections\/fypryst_b222167b-5510-448c-982d-70176a2c13fc.jpg?v=1701757774","url":"https:\/\/zuzu.land\/en-fr\/collections\/fypryst.oembed","provider":"ZuZu.land","version":"1.0","type":"link"}