{"product_id":"fypryst-combo-spot-on-antiparasitic-drops-pipettes-for-dogs-20-40kg","title":"Fypryst Combo Spot-on for dogs 20-40 kg 268 mg N1","description":"\u003cp\u003eFypryst Combo Spot-on for dogs 20-40 kg 268 mg N1\u003c\/p\u003e\n\u003cp\u003eMeans against fleas, ticks for dogs - Fypryst combo dog 268\/241.2 mg (20-40 kg), 1 pip., non-prescription vet. medicine - reg. NO - VA - 089588\/1\u003cbr\u003e\u003cbr\u003eNAME OF THE VETERINARY MEDICINE\u003cbr\u003eFypryst Combo 268 mg\/241.2 mg topical solution for large dogs.\u003cbr\u003e\u003cbr\u003eQUALITATIVE AND QUANTITATIVE COMPOSITION\u003cbr\u003eOne 2.68 ml pipette contains:\u003cbr\u003e\u003cbr\u003eActive substances:\u003cbr\u003eFipronil 268 mg;\u003cbr\u003eS-methoprene 241.2 mg.\u003cbr\u003eExcipients:\u003cbr\u003e\u003cbr\u003eButylhydroxyanisole (E320) 0.54 mg;\u003cbr\u003eButylhydroxytoluene (E321) 0.27 mg;\u003cbr\u003ePovidone (K25);\u003cbr\u003ePolysorbate 80;\u003cbr\u003eEthyl alcohol 96%;\u003cbr\u003eDiethylene glycol monoethyl ether.\u003c\/p\u003e\n\u003cp\u003ePHARMACEUTICAL FORM\u003cbr\u003eSolution for instillation on the skin.\u003cbr\u003eClear, yellow solution.\u003cbr\u003e\u003cbr\u003eTARGET SPECIES\u003cbr\u003eDogs 20-40 kg.\u003cbr\u003e\u003cbr\u003eINDICATIONS\u003cbr\u003eFor the prevention of flea infestations and mixed infestations of fleas and ticks and\/or lice.\u003cbr\u003eFor the treatment of flea (Ctenocephalides spp.) infestation. The effect of the insecticide against the infestation of young adult fleas remains for 8 weeks. For the prevention of flea reproduction by inhibiting the development of eggs (ovicidal action), larvae and pupae (larvicidal action) from eggs laid by adult fleas, 8 weeks after application.\u003cbr\u003eFor the treatment of tick (Ixodes ricinus, Dermacentor variablis, Dermacentor reticulatus, Rhipicephalus sanguineus) infestation. The acaricidal effect of this drug against ticks remains for 4 weeks.\u003cbr\u003eFor the treatment of lice (Trichodectes canis) infestation. This veterinary medicine can be used as part of a treatment strategy for flea allergy dermatitis if it has been previously diagnosed by a veterinarian.\u003c\/p\u003e\n\u003cp\u003eCONTRAINDICATIONS\u003cbr\u003eDue to a lack of data, this veterinary medicinal product should not be used in puppies under 8 weeks of age and\/or puppies weighing less than 2 kg.\u003cbr\u003eDo not use in sick animals (systemic diseases, fever, etc.) and animals in the recovery period.\u003cbr\u003eDo not use in rabbits, as side effects and even death are possible.\u003cbr\u003eIn the absence of studies, the use of this medicinal product is not recommended in animals other than the target species.\u003cbr\u003eThis medicine is for use in dogs only. Do not use in cats and ferrets, as overdose is possible.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003eSPECIAL PRECAUTIONS FOR USE\u003cbr\u003eSpecial precautions for use in animals:\u003cbr\u003e\u003cbr\u003eAvoid getting the medicine into the animal's eyes.\u003cbr\u003eIt is important to make sure that the medicine is applied in a place where the animals cannot lick it and to ensure that the animals do not lick each other after treatment.\u003cbr\u003eSpecial precautions to be taken by a person using veterinary medicinal products for the treatment of animals:\u003cbr\u003e\u003cbr\u003eThis medicine can cause irritation of the mucous membrane, skin and eyes, so avoid contact of the medicine with the mucous membrane of the mouth, skin and eyes.\u003cbr\u003ePersons with known hypersensitivity to insecticides or alcohol should avoid contact with this veterinary medicinal product. Be careful not to let the medicine come into contact with the skin. If this has happened, wash your hands with soap and water.\u003cbr\u003eIf the medicine accidentally gets into the eyes, rinse the eyes thoroughly with clean water.\u003cbr\u003eWash hands after use.\u003cbr\u003eDo not smoke, drink or eat during treatment.\u003cbr\u003eTreated animals should not be petted until the application site is dry, and children should not be allowed to play with freshly treated animals. For this reason, it is recommended to treat animals not during the day, but early in the evening, and not to allow recently treated animals to sleep with their owners, especially children.\u003c\/p\u003e\n\u003cp\u003eOther Precautions:\u003cbr\u003eFipronil and S-methoprene may be hazardous to aquatic organisms. Dogs should not be allowed to swim in water for two days after taking the medicine.\u003cbr\u003ePOSSIBLE SIDE EFFECTS\u003cbr\u003e\u003cbr\u003eAmong the very rare (less than 1 animal in 10,000 animals treated, including individual reports) possible side effects after the use of the drug, transient skin reactions at the application site (skin discoloration, local alopecia, pruritus, erythema) and generalized itching or hair loss have been reported. Increased salivation, depression, reversible neurological symptoms (increased sensitivity, depression, nervous symptoms), vomiting or respiratory symptoms have also been observed after taking the drug.\u003cbr\u003eIn case of licking the application site, temporary increased salivation may be observed mainly due to the properties of the carrier.\u003c\/p\u003e\n\u003cp\u003eUSE DURING PREGNANCY, LACTATION OR LAYING\u003cbr\u003eMay be used during pregnancy and lactation.\u003cbr\u003e\u003cbr\u003eINTERACTIONS WITH OTHER DRUGS AND OTHER TYPES OF INTERACTIONS\u003cbr\u003eNot known.\u003cbr\u003e\u003cbr\u003eDOSAGE AND METHOD OF ADMINISTRATION\u003cbr\u003eDosage:\u003cbr\u003eFor external use only (instillation).\u003cbr\u003eUse by applying to the skin; one 2.68 ml pipette (268 mg fipronil + 241.2 mg (S)-methoprene) for a dog with a body weight above 20 kg and up to 40 kg.\u003cbr\u003eThis corresponds to the minimum recommended dose of 6.7 mg\/kg fipronil and 6 mg\/kg (S)-methoprene for dermal application.\u003cbr\u003eDue to the lack of drug safety studies, the minimum interval between applications is 4 weeks.\u003c\/p\u003e\n\u003cp\u003eMethod of use:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRemove the pipette from the package. Hold the pipette vertically with the cap upwards, unscrew and remove the cap.\u003c\/li\u003e\n\u003cli\u003eTurn the cap upside down and put the other end back on the pipette. Press and twist the cap to break the seal and then remove the cap from the pipette.\u003c\/li\u003e\n\u003cli\u003eApply to the skin at the base of the neck in front of the shoulder blades.\u003c\/li\u003e\n\u003cli\u003ePart the hair so that the skin is visible. Place the tip of the pipette on the skin and squeeze the single-dose pipette several times to empty the contents directly onto the skin at one point.\u003c\/li\u003e\n\u003cli\u003eTransient changes in the coat (sticky\/greasy coat) may appear at the site of application.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eOVERDOSE\u003cbr\u003eIn laboratory studies on the safety of the drug, no side effects were observed in 8-month-old puppies, growing dogs, and dogs weighing around 2 kg, at a single dose of five times the recommended dose.\u003cbr\u003eThe risk of side effects can increase with an overdose of the drug, so choose the most suitable pipette size for animals, taking into account the animal's body weight.\u003cbr\u003ePHARMACOLOGICAL PROPERTIES\u003cbr\u003e\u003cbr\u003ePharmacotherapeutic group: means against ectoparasites for external use, including insecticides.\u003c\/p\u003e\n\u003cp\u003ePharmacodynamic properties:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFipronil is an insecticide and acaricide belonging to the phenylpyrazole group. It interacts with ligand-gated chloride channels, especially those regulated by the neurotransmitter gamma-aminobutyric acid (GASS), thereby blocking the pre- and postsynaptic transfer of chloride ions across cell membranes. It causes uncontrolled central nervous system activity and death in insects and mites. Fipronil kills fleas within 24 hours, ticks (Dermacentor variablis, Dermacentor reticulatus, Rhipicephalus sanguineus, Ixodes ricinus) and lice 48 hours after application.\u003c\/li\u003e\n\u003cli\u003e(S)-Methoprene is an insect growth regulator (IAR), from a class of compounds known as juvenile hormone analogues, which arrest the development of insects at one stage of development. This substance acts similar to juvenile hormones and causes impaired development and death of fleas at all stages of their development. The ovicidal effect of (S)-methoprene on the animal occurs either by direct penetration into newly laid eggs or by penetration through the cuticle into the body of an adult flea. (S)-methoprene effectively stops the further development of flea eggs and larvae, which protects against contamination of the immediate surroundings of animals with fleas in various stages of their development.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFypryst Combo Spot-on for dogs 20-40 kg 268 mg N1\u003c\/p\u003e","brand":"Fypryst","offers":[{"title":"Default Title","offer_id":46902985818437,"sku":"4016-1","price":7.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0552\/4327\/6372\/files\/lidzeklis-pret-blusam-ercem-suniem-fypryst-combo-dog-268-241-2-mg-20-40-kg-1-pip-bezrecepsu-vet-zales-reg-nr-va-072463-3-original_1cbf4a97-8787-444f-9a7c-c6101df9c165.jpg?v=1695300073","url":"https:\/\/zuzu.land\/en-gb\/products\/fypryst-combo-spot-on-antiparasitic-drops-pipettes-for-dogs-20-40kg","provider":"ZuZu.land","version":"1.0","type":"link"}