Fypryst Combo Spot-on antiparasitic drops (pipettes) for dogs 2-10 kg 67mg N1

Means against fleas, ticks for dogs - Fypryst combo dog 67/60.3 mg (2-10 kg), 1 pip., non-prescription vet. medicine - reg. NO - VA -089588/1

NAME OF THE VETERINARY MEDICINE
Fypryst Combo 67 mg/ 63 mg solution for instillation on the skin of small dogs.

QUALITATIVE AND QUANTITATIVE COMPOSITION
One 1.34 ml pipette contains:

Active substances:
Fipronil 67 mg;

Excipients:
Butylhydroxyanisole (E320) 0.134 mg;
Butylhydroxytoluene (E321) 0.067 mg;
Ethanol (96%)
Polysorbate 80
Povidone K25
Diethylene glycol monoethyl ether.

PHARMACEUTICAL FORM:
Solution for instillation on the skin.
Clear, yellow solution.

TARGET SPECIES:

Dogs 2-10 kg.

INDICATIONS:

• Fleas (Ctenocephalides felis) and ticks (Rhipicephalus species, Dermacentor species, Ixodes species)
• treatment and prevention of infestation in dogs.
• Treatment and control of allergy to flea bites in dogs (flea bite allergies).
• Prevention and treatment of lice (Trichodectes canis) infestation in dogs

CONTRAINDICATIONS:
As safety studies of this veterinary medicinal product have not been carried out, do not use in puppies under 8 weeks of age and/or
for puppies with a body weight of up to 2 kg.
Do not use in sick animals (systemic diseases, fever) or animals recovering
period.
Do not use in rabbits, as side effects and even death may occur.
This medicine is intended for dogs. Do not use in cats, as overdose is possible.

SPECIAL PRECAUTIONS FOR USE:

Special precautions for use in animals:
Avoid getting the medicine into the animal's eyes.
It is important to make sure that the medicine is applied in a place where the animals cannot lick it and to ensure that the animals do not lick each other after treatment.

Special precautions to be taken by a person using veterinary medicinal products for the treatment of animals:

This medicine can cause irritation of the mucous membrane, skin and eyes, so avoid contact of the medicine with the mucous membrane of the mouth, skin and eyes.
Persons with known hypersensitivity to insecticides or alcohol should avoid contact with this veterinary medicinal product. Be careful not to let the medicine come into contact with the skin. If this has happened, wash your hands with soap and water.
If the medicine accidentally gets into the eyes, rinse the eyes thoroughly with clean water.
Wash hands after use.
Do not smoke, drink or eat during treatment.
Treated animals should not be petted until the application site is dry, and children should not be allowed to play with freshly treated animals. For this reason, it is recommended to treat animals not during the day, but early in the evening, and not to allow recently treated animals to sleep with their owners, especially children.

POSSIBLE SIDE EFFECTS:

• In the case of licking, temporary hypersalivation (excessive salivation) can be observed mainly
• due to the properties of the ingredients.
• Among the very rare side effects reported after use are transient skin reactions
• application site (scaling, local alopecia, pruritus, erythema) and generalized pruritus or alopecia.
• In some cases, increased hypersalivation was observed after use, reversible neurologically
• symptoms (hypersensitivity, depression, nervous symptoms) or vomiting.
• Do not overdose!

USE DURING PREGNANCY, LACTATION OR LAYING:
May be used during pregnancy and lactation.

INTERACTIONS WITH OTHER DRUGS AND OTHER TYPES OF INTERACTIONS:
Not known.

DOSAGE AND METHOD OF USE:
Dosage:

• One single-dose pipette with 0.67 ml of solution for instillation on the skin of dogs with a body weight of 2 to 10 kg.
• This will give you the minimum recommended fipronil dose of 6.7 mg/kg.
• Since there have been no studies on the safety of the drug, the minimum interval between applications is 4 weeks.
• If there is a high risk of repeated flea infestation, if the dog is allergic to flea bites, if necessary
• tick infestation control or if the dog is washed frequently using hypoallergenic or emollients
• shampoos, recommended treatment once a month. In areas where there is no serious risk of flea and tick infestation,
• Fypryst solution for drops on the skin can be used once every two or three months.

Method of use:

Remove the pipette from the package. Hold the pipette vertically with the cap upwards, unscrew and remove the cap.
Turn the cap upside down and put the other end back on the pipette. Press and twist the cap to break the seal and then remove the cap from the pipette.
Apply to the skin at the base of the neck in front of the shoulder blades.
Part the hair so that the skin is visible. Place the tip of the pipette on the skin and squeeze the single-dose pipette several times to empty the contents directly onto the skin at one point.
Transient changes in the coat (sticky/greasy coat) may appear at the site of application.

OVERDOSE:
In laboratory studies on the safety of the drug, no side effects were observed in 8-month-old puppies, growing dogs, and dogs weighing around 2 kg, at a single dose of five times the recommended dose.
The risk of side effects can increase with an overdose of the drug, so choose the most suitable pipette size for animals, taking into account the animal's body weight.

PHARMACOLOGICAL PROPERTIES:
Pharmacotherapeutic group: means against ectoparasites for external use, including insecticides.

Pharmacodynamic properties:

• After topical application of Fypryst solution to the skin in dogs, fipronil moderate (15% by volume)
• absorbed. Different concentrations of fipronil have been observed in the blood plasma of dogs.
• After application of Fypryst solution to the skin, fipronil by concentration gradient mechanism
• on animal skin and hair spreads from the application area to the peripheral areas (hip area,
• groins, etc.).
• In dogs, fipronil is primarily metabolized to its sulfone (RM 1602), which also has
• insecticide and acaricidal effect.
• 56 days after application, the concentration of fipronil in the hair of dogs decreases to approximately 3-4 μg/g.